THE SATIETY SIGNAL
Cagrilintide
Long-acting appetite suppressant for serious weight loss
Also known as: Acylated amylin analog
Overview
Cagrilintide is a modified version of amylin, a hormone your pancreas releases after eating. It tells your brain you're full, slows stomach emptying, and improves blood sugar control. Combined with GLP-1 drugs like semaglutide, it can produce dramatic weight loss results (up to 15% body weight).
Key Benefits & Mechanisms
Appetite Control
Activates satiety centers in the brain to reduce hunger
Gastric Slowing
Delays stomach emptying so you feel full longer
Blood Sugar
Suppresses glucagon and improves insulin sensitivity
Dosing Guide
Dosage
2.4 mg once weekly (subcutaneous)
Schedule
weekly
Cycle
8+ weeks (ongoing treatment)
Pro Tip
Often combined with semaglutide for enhanced effects; inject on same day each week
Safety Profile
Good Safety
Good
Well-tolerated in clinical trials. Being developed by Novo Nordisk.
Still in clinical development. Works best when combined with GLP-1 agonists.
Possible Side Effects
What to Expect
Week 1
Reduced appetite and food intake
Week 4-8
Noticeable weight loss (3-5%)
Week 12+
Significant weight loss (10-15% with GLP-1 combo)
Appetite reduction within first week; significant weight loss by 8-12 weeks.
Who Is This For
Research References
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