Sculpt & Burn

Intermediate
28 week cycle2 peptides6 starts

Overview

Combines a powerful GLP-1/GIP/glucagon tri-agonist with a mitochondrial-targeting peptide to support comprehensive weight loss and metabolic optimization. Designed for individuals seeking significant fat loss while preserving lean muscle mass, improving insulin sensitivity, and enhancing cellular energy production.

Stack Synergy

Retatrutide drives caloric reduction and hormonal optimization while MOTS-c ensures your cells efficiently burn the fat being mobilized and maintain metabolic health during weight loss.

Benefits

Significant and sustained fat loss while preserving lean muscle mass
Reduced appetite and improved satiety signals
Enhanced insulin sensitivity and blood sugar regulation
Increased metabolic flexibility and fat oxidation capacity
Improved mitochondrial function and cellular energy production
Better exercise tolerance and recovery

Peptides in This Protocol

Phase Timeline

Initiation

Day 114
+14d hold
Assess tolerance and prime mitochondrial pathways

Start low to assess tolerance and activate metabolic pathways.

Retatrutide
1x/week
1 mg1x/weekflexible1x/week

Inject 1 mg subcutaneous once weekly. Start with lowest dose to assess GI tolerance.

MOTS-c
2x/week
5 mg2x/weekflexible2x/week

Inject 5 mg subcutaneous twice weekly (e.g., Monday and Thursday) to prime mitochondrial function.

Active Fat Loss

Day 1570
+14d hold
Maximize fat oxidation, preserve lean muscle, and optimize metabolic flexibility

Full therapeutic dosing to drive consistent weight loss and metabolic improvement.

Retatrutide
1x/week
2.5 mg1x/weekflexible1x/week

Inject 2.5 mg subcutaneous once weekly. Therapeutic dose for active weight loss.

MOTS-c
4x/week
5 mg4x/weekflexible4on3off

Inject 5 mg subcutaneous 4 days per week (e.g., Monday, Tuesday, Thursday, Friday) for full metabolic optimization.

Consolidation

Day 71154
+14d hold
Stabilize at lower body weight and reinforce healthy metabolic patterns

Lock in your progress and let your body adapt to a new metabolic baseline.

Retatrutide
1x/week
1 mg1x/weekflexible1x/week

Inject 1 mg subcutaneous once weekly. Maintenance dose to sustain weight loss.

MOTS-c
2x/week
5 mg2x/weekflexible2x/week

Inject 5 mg subcutaneous twice weekly. Tapers to zero by week 20. Follow clinician guidance for step-down.

Taper

Day 155196
+14d hold
Gradually taper while maintaining metabolic adaptations

Gentle step-down to preserve your results long-term.

Retatrutide
1x/week
0.5 mg1x/weekflexible1x/week

Inject 0.5 mg subcutaneous once weekly. Gradual taper to maintain metabolic adaptations.

Who Is This For

intermediate level

2 peptides with phased dosing schedules requiring careful titration and monitoring.

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